“Bring My Flowers Now,” Tanya Tucker Best Country Duo/Group Performance “Ride Me Back Home,” Willie Nelson *WINNER Yola COUNTRY Best Country Solo Performance “Truth Hurts,” Steven Cheung, Eric Frederic, Melissa Jefferson & Jesse Saint John Best new artist “Someone You Loved,” Tom Barnes, Lewis Capaldi, Pete Kelleher, Benjamin Kohn & Sam Roman “Norman F***ing Rockwell,” Jack Antonoff & Lana Del Rey “Hard Place,” Ruby Amanfu, Sam Ashworth, D. “Bring My Flowers Now,” Brandi Carlile, Phil Hanseroth, Tim Hanseroth & Tanya Tucker “Bad Guy,” Billie Eilish O’Connell & Finneas O’Connell *WINNER “Always Remember Us This Way,” Natalie Hemby, Lady Gaga, Hillary Lindsey & Lori McKenna “Father of the Bride” - Vampire Weekend Song of the year “When We All Fall Asleep Where Do We Go” - Billie Eilish “Sunflower” - Post Malone & Swae Lee Album of the year
“Old Town Road” - Lil Nas X & Billy Ray Cyrus Check back for updates on the winners throughout the night. (CNN) - The 62nd Annual Grammy Awards are underway, being held Sunday night at the Staples Center in Los Angeles.Ī list of some of the major categories follows below. Please look at the time stamp on the story to see when it was last updated. This work was funded by the National Cancer Institute and a Pelotonia Idea Grant.This is an archived article and the information in the article may be outdated. Other Ohio State researchers who worked on this study are a lead author, Vedud Purde, and David Heisler and Reena Shakya. But if biochemists can find a way to get both pieces of the protein to enter a cancer cell, the two pieces of toxin can then destroy the cancer. The specific delivery of this other part in sufficient quantity is yet to be achieved and is being pursued in the laboratory.”Įssentially, when the toxin protein is split and goes into the human body as a cancer treatment, it can’t cause harm to healthy cells. “What we have achieved so far is the reconstruction of the fully functional toxin upon specific delivery of one part of the split immunotoxin to the cells expressing the other part. “But to achieve that, both parts must enter cancer cells,” Kudryashova said. But when they recombine into the original toxin, the treatment destroys the cancer. “We have confirmed that when separated, the parts of the split toxin do not harm cells.
The key to split immunotoxins is that only cancer cells will receive both parts of the split toxin, said Elena Kudryashova, a co-senior author on the study and a research scientist at Ohio State. “What is difficult is to kill only the cancer cells and nothing else.”Īnd while some cancer treatments have been successful at targeting cancer cells, few have been able to do so without also affecting healthy cells. “The problem is not to kill the healthy cells,” said Dmitri Kudryashov, an associate chemistry professor at The Ohio State University and senior author of the study. That destruction often causes life-threatening side effects. The search for a cancer cure has led to a number of treatments that destroy cancer cells, but also destroy healthy, non-cancerous cells. The research was designed as a proof-of-concept study, but the researchers found that the functional toxin can be reconstructed in cancer cells in both laboratory cell cultures and in mice. The immune substance attaches to cancer cells, allowing the toxin to enter the cancer cell and kill it without harming nearby healthy cells. Immunotoxins combine an immune substance with a toxin. 24, in the Proceedings of the National Academy of Sciences, suggests that splitting immunotoxins into two inactive and benign parts may set the stage for future, targeted treatments of cancers. Splitting one type of cancer drug in half and delivering the pieces separately to cancer cells could reduce life-threatening side effects and protect healthy, non-cancerous cells, a new study suggests.
0 kommentar(er)
